Features of application
Futsis( fluconazole) analogs:
Futsis( fluconazole) instruction:
"Liva Healthcare Ltd.", India
"Kusum Healthcare", India
Active substance Fucis
Release forms Fucis
Tablets 50 mg, 100 mg, 150 mg, 200 mg No. 4 in strips
Tablets soluble 50mg No. 4 d strips
Solution for infusion 0.2% to 50 mlIs 100 ml vials
Who can Futsis
- infections caused by Candida, including Generalized candidiasis including candidemia;
- disseminated candidiasis and other forms of invasive candidiasis infection( infections: generalized, endocardium, eye, respiratory and urinary tract);
- Candidiasis of the mucous membranes, including oral cavity and throat, esophagus;
- non-invasive bronchopulmonary infections;
- mucocutaneous and chronic atrophic candidiasis of the oral mucosa( associated with the wearing of dentures);
- genital candidiasis - vaginal candidiasis( acute or recurrent),
- prevention of recurrences of vaginal candidiasis( at a frequency of occurrence of 3 times or more per year), as well as candidiasis balanitis;
- cryptococcal meningitis and cryptococcal infection of other localization
- dermatomycosis, including mycosis of legs, body, inguinal region, lichen;
- deep endemic mycoses, including coccidioidomycosis, paracoccidioidomycosis, sporotrichosis and histoplasmosis;
prophylaxis of fungal infections in patients who receive cytostatic or radiotherapy, and in patients with AIDS.
How to use Fucis
Side effects of Fucis
Fucis, as a rule, is well tolerated.
However, headache, abdominal pain, diarrhea, flatulence, nausea, vomiting, toxic liver damage( changes in laboratory parameters - increased levels of alkaline phosphatase, bilirubin, aminotransferases), and hepatitis can occur most often from side effects.
There may also be dizziness, convulsions;alopecia, exfoliative skin reactions;change in the number of leukocytes( neutropenia, agranulocytosis), blood platelets;allergic reactions( skin rash, itching, face swelling, anaphylaxis), increased cholesterol, triglyceride, potassium in the blood;changes in taste.
To whom is contraindicated Fucis
- hypersensitivity to fluconazole or close to it in structure azole compounds;
- simultaneous use of terfenadine by patients who receive fluconazole therapy at a dose of 400 mg / day or more;
- hepatic insufficiency;
- children under 7 years.
Interaction with other drugs
Simultaneous reception of warfarin and fluconazole increases prothrombin time;fluconazole and oral hypoglycemic preparations of the group of urea sulfonyl derivatives( chlorpropamide, glibenclamide, glipizide and tolbutamide) prolongs the half-life of them( it is worth considering the possibility of developing hypoglycemia).
Fluconazole and phenytoin - clinically significantly increase the concentration of phenytoin( concentration monitoring and dose selection are necessary).Multiple use of hydrochlorothiazide increases the concentration of fluconazole in blood plasma, however, a change in the dosage regimen of fluconazole is generally not necessary. Fluconazole at a dose of 50-200 mg does not significantly affect the effectiveness of combined oral contraceptives.
Simultaneous application of fluconazole and rifampicin resulted in a 25% decrease in AUC and a 20% decrease in the half-life of fluconazole. Patients who use this combination of drugs should consider the advisability of increasing the dose of fluconazole.
During the administration of fluconazole, it is recommended to monitor the concentration of cyclosporin in the blood.
When treating fluconazole patients who receive theophylline in high doses, or patients at increased risk of toxic theophylline, it is necessary to control the symptoms of theophylline overdose;If they occur, therapy should be changed accordingly.
Given the occurrence of severe arrhythmias caused by prolonged QT interval, concomitant administration of fluconazole 400 mg / day and above from terfenadine is contraindicated in patients who received AZ antifungal agents in combination with terfenadine.
Treatment with fluconazole at a dose below 400 mg / day in combination with terfenadine should be performed under the strict supervision of a physician. With the simultaneous use of fluconazole and cisapride, adverse reactions from the cardiovascular system are possible, including paroxysms of gastric tachycardia. The use of fluconazole in patients who simultaneously receive cisapride, astemizole, rifabutin, tacrolimus, or other drugs metabolizing the cytochrome P450 system may be accompanied by an increase in the concentration of these drugs in the blood.
Simultaneous administration of cimetidine or antacid has no clinically significant effect on the absorption of fluconazole.
Defined by hallucinations and paranoid behavior. Treatment is symptomatic( including maintenance therapy and gastric lavage).Fluconazole is excreted mainly with urine, therefore forced diuresis can speed up the elimination of the drug. A hemodialysis session lasting 3 hours reduces the plasma fluconazole level by approximately 50%.