Grippostad C( paracetamol comb) analogs:
Grippostad C( paracetamol comb) Instruction:
Active substance Grippostad
Paracetamol, ascorbic acidand, caffeine, chlorpheniramine maleate;
Forms of Grippostad
Who is shown Grippostad
Symptomatic treatment of influenza and acute respiratory infections and upper respiratory tract.
How to use Grippostad
How to use and dose.
The initial dose for children over 12 years and adults is 2 capsules three times a day: morning, afternoon and evening.
As symptoms disappear, dosage may be reduced to 1 capsule in the morning, afternoon and evening. Capsules should be taken with a sufficient amount of liquid. The maximum course of t
Grippostad C should be given with extreme caution:
- if liver function is impaired;
- patients with kidney disease, diabetes mellitus;
- with an elevated level of bilirubin in the blood( Gilbert's syndrome).
Effect on the ability to drive vehicles and work with machinery.
Grippostad C, even when used for its intended purpose, can change the response ability in such a way that the ability to drive vehicles and operate machinery is reduced.
Ascorbic acid can change the test results for blood glucose, bilirubin, transaminase.
During treatment, alcohol is contraindicated.
Side effects of Grippostad
Rarely - thrombocytopenia, leukopenia, agranulocytosis and pancytopenia.
Gastrointestinal disorders, weakness, dry mouth, increased intraocular pressure, skin hypersensitivity reactions and difficulty urinating.
In some cases, there are reactions of hypersensitivity to the active substances of the drug - allergic reactions.
In some cases, spasms of bronchial tubes, leukocytosis, hyperglycemia, erythrocytopenia may occur.
To whom is contraindicated Grppostad
- Hypersensitivity to paracetamol and excipients included in the preparation.
- Violation of the functions of the liver and kidneys.
- Congenital insufficiency of glucose-6-phosphate dehydrogenase.
- Increased intraocular pressure( glaucoma);hypertrophy of the prostate with a delayed residual urine.
- Because the preparation contains lactose, it is contraindicated in patients with hereditary galactose diabetes, malabsorption of lactose and malabsorption of glucose-galactose.
- Alcoholism, thrombophlebitis, propensity to thrombosis.
- Pregnancy and lactation.
- Children under 12 years.
With the simultaneous use of antidepressants and MAO inhibitors, there is an effect on the central nervous system, which is accompanied by increased excitation, high temperature, and changes in the function of respiration and circulation.
In combination with sleeping pills and antiepileptic drugs( with phenobarbital, phenytoin, carbamazepine), as well as with anti-tuberculosis drugs( with rifampicin), generally harmless doses of paracetamol can cause liver damage. This also applies to alcohol abuse.
Simultaneous use with drugs that slow down the release of the stomach( propantheline) can inhibit the absorption of paracetamol, which slows the onset of action.
Simultaneous use with drugs that accelerate the release of the stomach( metoclopramide), accelerate the resorption of paracetamol.
The combined use of paracetamol and chloramphenicol can significantly reduce the excretion of chloramphenicol from the body and, thus, increase its toxicity. Paracetamol increases the effect of indirect anticoagulants.
Elevated doses of paracetamol can lead to intoxication with a delay of 24 to 48 hours.
After receiving large doses, hepatocellular necrosis and necrosis of tubular kidney cells develops.
The initial stage( the first day) of an overdose of paracetamol can be accompanied by nausea, vomiting, active perspiration, drowsiness, general weakness.
Despite the fact that the second day is sometimes characterized by subjective improvement of well-being, slight pain in the abdominal area, liver enlargement, increased transaminase and bilirubin levels, increased thromboplastin time, and decreased urination may occur.
The third day: the activity of transamylase, jaundice, blood clotting disorders, hypoglycemia and the development of hepatic coma may increase.
After an overdose, anticholinergic components cause symptoms similar to those caused by atropine: blush, frozen extended pupils, dry mouth and constipation. Then signs of CNS intoxication may appear( hallucinations, coordination of movement and convulsions)
Increased doses of caffeine cause anxiety, confusion, trembling, and in some cases, cardiac arrhythmia
Ascorbic acid( Vitamin C):
Ascorbic acid is water-solublevitamin and is practically non-toxic
Emergency assistance with intoxication:
It is necessary to wash the stomach for 6 hours after the drug, intravenous injection of group donatorsSH( cystamine, acetylcysteine) within 8 hours after using the drug, dialysis reduces the concentration of paracetamol in the blood. It is recommended to quantify paracetamol in the blood.