Driptan( oxybutynin) instruction:
Manufacturer:Laboratoires Fournier, France
Active substance Driptanoxybutynin hydrochloride.
Formulation of DriptanTablets of 5 mg No. 30
To which Driptan is shown
Urinary incontinence, urination, urination and polukiyuriya( accelerated urination) in cases of unstable bladder function of a neurogenic origin or as a result of idiopathic instability of detrusor function.
Nocturnal enuresis in children( older than 5 years).
How to use Driptan
Method of administration and dose.
Is used orally.
Adults. The initial dose is 2.5 mg, 3 times a day. It can be increased, if necessary, to the
In persons of advanced years, the half-life of the drug may be increased, so it is recommended to start treatment with a dose of 2.5 mg 2 times a day. It can be increased, if necessary, to the lowest effective dose, which gives a satisfactory clinical effect. Usually, a dose of 5 mg twice a day is sufficient, at least in patients with a low body weight.
Children over 5 years old. The initial dose is 2.5 mg, 3 times a day. It can be increased, if necessary, to the lowest effective dose, which gives a satisfactory clinical effect. The recommended dose is from 0.3 to 0.4 mg / kg of body weight per day.
The maximum doses are indicated in the table below.
2.5 mg 3 times daily
Children younger than 5 years. The use of this drug is not recommended.
Feasibility of treatment Driptan should be reviewed every 4-6 weeks, as the function of the bladder in some patients can be normalized. Driptan can not be used to treat stress urinary incontinence.
The drug should be administered with caution to elderly patients who may be more sensitive to the effects of oxybutynin, as well as to patients with neurocirculatory dystonia, hernia of the esophagus or other serious gastrointestinal diseases, liver and kidney disease, tachyarrhythmias or cerebral circulatory insufficiency.
Against the backdrop of Driptan, clinical manifestations of hyperthyroidism, heart disease, arrhythmias, tachycardia, chronic heart failure and prostatic hyperplasia are likely to increase.
Long-term use of Driptan can cause oral discomfort due to insufficient salivation, which can provoke tooth decay, periodontitis or candidiasis of the oral mucosa.
In case of a urinary tract infection, antibacterial therapy should be prescribed.
Because of the presence of lactose, this drug should not be taken with hereditary intolerance to galactose, malabsorption of glucose and galactose, or deficiency of lactase.
Safety of reception Driptan during pregnancy is not established. Animal studies found the appearance of embryotoxic effects in doses that were toxic to mothers. Therefore, during pregnancy Driptan is prescribed only in cases of extreme need. In animals, oxybutynin enters the mother's milk. Therefore, Driptan can not be administered during breastfeeding.
The drug may cause a decrease in visual acuity and drowsiness, which must be taken into account when driving or other mechanisms.
Side effects of Driptan
Side effects such as dry mouth, constipation, blurred vision, pupillary dilatation, tachycardia, nausea, discomfort in the abdomen, flushing of the face( more pronounced in children than in adults) can occur most often,anxiety and difficulty urinating.
Dose reduction reduces the incidence of these side effects.
Less common is headache, urinary retention, dizziness, drowsiness, dry skin, diarrhea, and cardiac arrhythmias.
Sometimes there may be an increase in intraocular pressure, the development of glaucoma( closed-angle), the appearance of convulsions, hallucinations and nightmares.
Cognitive impairment( confusion, anxiety, paranoia) has sometimes occurred in people in advanced years.
In rare cases, allergic skin reactions were observed.
To whom is contraindicated Dripton
The drug is not prescribed in such cases:
- hypersensitivity to oxybutynin or to one of the excipients;
- risk of urinary retention associated with diseases of the urethra and prostate, intestinal obstruction, toxic megacolon, intestinal atony, severe ulcerative colitis, myasthenia gravis, known risk of angle-closure glaucoma.
When used concomitantly with a lizard, there is a risk of impairment of consciousness, therefore regular clinical monitoring of patients is necessary.
With simultaneous use with atropine and other atropine-like drugs( antidepressants of the inaprimin group, sedative H1-antihistamines, atropine-like antispasmodics, other anticholinergics for the treatment of parkinsonism, disopyramide, phenothiazine antipsychotics), there may be additional side effects of atropine: urinary retention, constipation, drynessmouth.
Symptoms. With an overdose Driptana may increase the severity of side effects and the appearance of signs of atropine intoxication( dilated pupils, a sharp decrease in the secretion of secretions, paralysis of smooth muscles).
Treatment. Gastric lavage, slow intravenous injection of 1-2 mg physostigmine( if necessary, repeat, up to 5 mg maximum).Children are recommended intravenous slow injection of physostigmine at a dose of 30 mcg / kg( if necessary - repeated, up to 2 mg maximum).
In the case of fever, symptomatic therapy is performed. With severe anxiety or excitation, 10 mg of diazepam is injected intravenously. When tachycardia intravenously administered propranolol. When the urine is delayed, the bladder is catheterized.
In the case of development of paralysis of the respiratory muscles, artificial ventilation is performed.