Doxibene( doxycycline)

Doxibene( doxycycline) analogues:

Doxibene( doxycycline) Instruction:


"Eurand S.p. A."for "Merckle GmbH" / "ratiopharm GmbH", Italy / Germany

Active ingredient Doxibene


Forms of release Doxibene

Capsules of 100 mg, 200 mg No 5

To which Doxibene is exposed

Infections caused by bacteria that are sensitive to doxycycline:

pneumonia, bronchitis, tonsillitis, inflammation of the paranasal sinuses, otitis media, cholera, cholecystitis and cholangitis, diarrheadysbiosis, gonorrhea, syphilis, pyelonephritis, cystitis, urethritis, prostatitis, epididymitis, adnexitis, infectious skin diseases( for example, rosacea or acne), soft tissues and joints, eye infections( trachoma), and specific infections( brucellosis, tularemia, plague, sibleeding ulcer, gas gangrene).

How to use Doxibene

Method of administration and dose.

The drug is taken with food.

Adults with a body w

eight of more than 70 kg: from the first day of treatment appoint 200 mg of doxycycline per day( respectively 2 capsules "Doxibene" for 100 mg or 1 capsule "Doxibene" for 200 mg).The daily dose( 200 mg) can be divided into 2 doses with an interval of 12 hours( corresponding to 2 capsules of "Doxibene" of 100 mg).

Adults and adolescents with a body weight of 50-70 kg: on the first day, 200 mg of doxycycline are taken( respectively 2 capsules of Doxibene 100 mg or 1 capsule of Doxibene 200 mg each).This dose can be taken for 1 reception, and for 2 doses with a break at 12 o'clock. In the future, take 100 mg of Doxibene once a day.

For treatment of children weighing up to 50 kg( at the age of 8 years): dosage forms for oral administration are not used because of their high dosage.

Special dosing.

  • Encephalitis( which is carried by ticks): 200 mg daily for 10-20 days.
  • Acute gonorrhea in women: 200 mg per day, for at least 7 days.
  • Acute urethritis in men caused by gonococci: daily, 200 mg of doxycycline, for 7 days.
  • Communicable diseases of the genital organs in men with impaired ability to fertilize an unclarified nature: 200 mg daily for 4 weeks( treatment of both sex partners).
  • Acute infectious diseases of the appendages caused by chlamydia and / or gonorrhea: 200 mg daily for 10 days.
  • Syphilis: 300 mg daily, for at least 10 days. The daily dose can be taken at a time.
  • Skin diseases( severe infected forms of acne and Rosacea: erysipelas): 100 mg daily for 7 to 21 days
  • Acute non-specific diseases of female genital organs: 200 mg daily for 10-14 days, in combination with othertypes of treatment that are prescribed by the doctor
  • Duration of treatment: in determining the duration of treatment, the type of disease, the extent and nature of its course should be taken into account

After the disappearance of the symptoms of the disease, treatment should continue 1 -3 days

If the infectious disease is caused by beta-hemolytic streptococci, treatment should be given for at least 10 days to prevent possible negative effects( eg, development of rheumatic fever or glomerulonephritis.)

Usage specificities

Caution is advised to prescribe the drug to patients with impairedheart rhythm, as well as patients taking digitalis preparations.

Admission during meals reduces the risk of abnormalities in the work of the gastrointestinal tract.

It is not recommended to prescribe the drug immediately before bedtime.

In case of development of superinfection caused by resistant microorganisms, the antibiotic should be discontinued and appropriate therapy should be prescribed.

Pseudomembranous colitis can develop with almost all antibiotics, including doxycycline. Therefore, it is necessary to exclude its presence in patients with diarrhea, which developed after taking antibiotics.

Catabolic effects of tetracyclines can cause an increase in the level of residual nitrogen in the blood.

During therapy with drugs containing doxycycline, sun and other types of ultraviolet irradiation should be avoided, as preparations of the tetracycline group can cause increased sensitivity to light( skin rashes, burns).

During pregnancy, breastfeeding, and children under the age of 8, doxycycline is prescribed only if there is a life-threatening condition and other antibiotics are not possible. The results of experimental studies indicate that tetracyclines penetrate the placenta, appear in the tissues of the embryo and can have a toxic effect on it( may lead to a delay in the development of the skeleton).Doxycycline should not be given during breastfeeding, as it can enter the breast milk.

Effect on the ability to drive.

There are reports of minor visual impairment when using tetracycline drugs, which should be considered if you are driving a car or working with complicated equipment.

Side effects of Doxibene

Nausea, vomiting, anorexia, glossitis, esophagitis, hypersensitivity such as photosensitivity, urticaria, swelling of the skin, mucous membranes or joints, asthma, anaphylactic manifestations( dyspnea, dizziness, lower blood pressure), itching, risingtemperature, headache and pain in the joints, in rare cases - angioedema.

With prolonged use, hemolytic anemia, thrombocytopenia, neutropenia, eosinophilia, superinfection caused by fungi or resistant bacteria can develop.

In the treatment of doxycycline, development of the fungus flora of the genus Candida on the skin and mucous membranes can take place. This can lead to candidiasis of the genital organs, inflammation of the mucous membranes of the mouth and tongue.

With prolonged treatment with doxycycline, attention should be paid to the possible lack of B vitamins.

In very rare cases, there may be a change in taste and smell.

When prescribing doxycycline for children under 8 years of age, in rare cases, an irreversible discoloration of the teeth and destruction of tooth enamel are observed, as well as reversible bone growth retardation.

To whom is contraindicated Doxibene

Hypersensitivity to doxycycline and other tetracyclines, severe violations of liver function, pregnancy, lactation period.

Interaction Doxibene

The drug may enhance the effect of indirect anticoagulants, hypoglycemic effect of sulfonylurea derivatives.

The drug exhibits antagonistic properties with respect to the bactericidal action of penicillins and cephalosporins. Doxycycline potentiates the effect of curare-like substances.

Simultaneous reception of antacids containing aluminum, calcium and magnesium, preparations containing iron and bismuth salts, violates the absorption of doxycycline.

In the treatment of acne with isotretinoin, a break must be maintained after therapy with doxycycline, since both drugs may in some cases lead to a reversible increase in intracranial pressure.

The simultaneous use of theophylline and doxycycline increases the risk of side effects from the gastrointestinal tract.

In rare cases, the effectiveness of contraceptive hormonal contraceptives may be reduced. In this regard, it is recommended to use non-hormonal contraceptives.

Doxibene can not be used concomitantly with drugs that adversely affect liver and kidney function.

The simultaneous use of tetracyclines and methoxyflurane may be accompanied by a significant nephrotoxic effect.

The half-life of doxycycline decreases with its combination with phenobarbital, carbamazepine, phenytoin, and chronic alcoholism.

Overdose of Doxibene

In case of an overdose, there is a risk of liver damage. When overdose occurs a more pronounced manifestation of the above side effects from the gastrointestinal tract. In intoxication, mainly standard symptomatic treatment is carried out, including gastric lavage, activated charcoal and maintenance therapy aimed at preserving vital functions. Since tetracycline is able to form chelate complexes with calcium salts, with intoxication as counteraction, calcium salts can be taken.