Pentalgin-ICN( metamizole sodium comb.)

Pentalgin-ISN( metamizole sodium comb.) Analogs:

Pentalgin-ISN( . Metamizole sodium comb) instruction:


Active ingredients Pentalgina-ICN:

Form of Pentalgina-ICN:

To whom is Pentalgin-ICN shown?

Moderately expressed pain syndrome of various genesis( including pain in joints, muscles, with radiculitis, menstrual pain, neuralgia, headache and toothache).

Hyperthermia with catarrhal conditions, which is accompanied by a febrile syndrome.

How to use Pentalgin-ICN?

The drug is taken orally. Usually take 1 tablet 1 to 3 times a day. The drug should be taken at intervals of at least 4 hours between meals and do not use more than 5 days as an anesthetic and more than 3 days as an antipyretic agent without prescribing and monitoring the doctor.

The maximum daily dose is 4 tablets.


When taking the drug during pregnancy and lac

tation, it is possible to penetrate the components of the drug( caffeine, phenobarbital, paracetamol) through the placenta into the fetus and develop a teratogenic effect in the fetus.

During the period of application of Pentalgin-ICN, it is not necessary to drive vehicles, service mechanical devices and perform work that requires a quick mental and physical reaction, because the drug slows down the reaction and causes drowsiness.

Who is contraindicated with Pentalgin-ICN?

Hypersensitivity, severe hepatic and / or renal failure, bronchial asthma, glucose-6-phosphate dehydrogenase deficiency, anemia, leukopenia, conditions accompanied by respiratory depression, craniocerebral hypertension, acute myocardial infarction, arrhythmias, hypertension, alcohol intoxication, glaucoma,pregnancy, the period of breastfeeding and children under 7 years.

With caution - peptic ulcer of the stomach and duodenum( in remission), elderly age.

Appropriate safety precautions for use.

For prolonged( more than 1 week) treatment, it is necessary to monitor the picture of peripheral blood and the functional state of the liver. The drug can change the results of doping control tests in athletes. It is difficult to establish a diagnosis for acute abdominal pain syndrome. In patients who suffer from atopic bronchial asthma, pollinosis, there is an increased risk of developing a hypersensitivity reaction.

Side effects of Pentalgin-ICN.

Allergic reactions( rash, itching, urticaria), dizziness, drowsiness, tachycardia, nausea, vomiting, constipation;Leukopenia, granulocytopenia, agranulocytosis. With prolonged uncontrolled use in high doses, addiction( weakening of the analgesic effect), drug dependence( codeine), hepatic and / or renal insufficiency.

Interaction of pentalgin-ICN.

With the simultaneous use of drugs that cause an inhibitory effect on the central nervous system( including sedatives and tranquilizers), it is possible to increase the sedative effect and depressant effect on the respiratory center.

Strengthens the effect of ethanol on the psychomotor response.

Simultaneous use with chlorpromazine or phenothiazine can lead to the development of severe hyperthermia.

Metamizole reduces the concentration of cyclosporine.

Metamizole, displacing from the binding sites with protein oral hypoglycemic drugs, indirect anticoagulants, GCS and indomethacin, increases their activity.

Tricyclic antidepressants, oral contraceptives, allopurinol disrupt metamizole metabolism in the liver and increase its activity.

Simultaneous use of the drug with other non-narcotic analgesics may lead to increased toxic effects.

Barbiturates, phenylbutazone and other inducers of microsomal liver enzymes weaken the effect of metamizole.

Overdose of Pentalgine-ICN.

Symptoms: nausea, vomiting, gastralgia, tachycardia, arrhythmia, oppression of the respiratory center.

Treatment: with the appearance of these symptoms, gastric lavage, the appointment of intestinal adsorbents and laxatives are prescribed. For specific treatment of an overdose of paracetamol, included in the composition, intravenously injected acetylcysteine ​​140 mg / kg and then 70 mg / kg every 4 hours.