Augmentin( amoxicillin + clavulanic acid) analogues:
Augmentin( amoxicillin + clavulanic acid) Instruction:
GlaxoSmithKline, United Kingdom
Amoxicillin + Clavulanic acid( Amoxicillin + Clavulanic acid)
D Forms of the preparation
- coated tablets, 500 mg + 125 mg: 14 or 20 pcs.
- tablets, coated, 250 mg + 125 mg: 20 pcs.
- tablets coated with shell, 875 mg + 125 mg: 14 pcs.
- powder for the preparation of a suspension for ingestion 125 mg + 31.25 mg / 5 ml: fl.
- powder for suspension for oral administration 200 mg + 28.5 mg / 5 ml: fl.
- powder for suspension for oral administration 400 mg + 57 mg / 5 ml: fl.
- powder for the preparation of the injection solution 0.6 g of fl., No. 10
- powder for the preparation of the injection solution of 1.2 g of fl., No. 5 and 10
To whom is shown Augmentin
Bacterial infections caused by susceptible microorganisms to the preparation: upper respiratory tract infections- Acute and chronic bronchitis( inflammation of the bronchi), lobar bronchopneumonia( combined inflammation of the bronchi and lungs), empyema( accumulation of pus), abscesses( abscesses) of the lungs;Bacterial infections of the skin and soft tissues;
infections of the genitourinary tract: cystitis( inflammation of the bladder), urethritis( inflammation of the urethra), pyelonephritis( inflammation of the kidney and renal pelvis);Sepsis( contamination of blood by microbes from the focus of purulent inflammation) with abortion, infection of the pelvic organs, syphilis, gonorrhea;Osteomyelitis( inflammation of the bone marrow and adjacent bone tissue);Septicemia( the form of infection of blood by microorganisms);Peritonitis( inflammation of the peritoneum);Postoperative infections.
How to use Augmentin
Before prescribing a drug to a patient, it is desirable to determine the sensitivity of the microflora that caused the disease to it. The doses are set individually depending on the severity of the course, the localization of the infection and the sensitivity of the pathogen.
Oral administration of
For children younger than 1 year, the drug is administered as a drop. Single dose for children up to 3 months.- 0,75 ml, for children from 3 months. Up to a year - 1,25 ml. In severe cases, an intravenous single dose for children aged 3 months. Up to 12 years is 30 mg / kg body weight;The drug is injected every 6-8 hours. Children under 3 months are given a single dose of 30 mg / kg of body weight: premature and perinatal( 7th day of life of newborns) every 12 hours, then every 8 hours. TreatmentThe drug should not be continued for more than 14 days without reviewing the clinical situation.
Children under the age of 12 years are prescribed a drug in the form of a syrup or suspension. A single dose depends on the age and is: for children aged 7-12 years - 10 ml( 0.156 g / 5 ml) or 5 ml( 0.312 g / 5 ml);For children aged 2-7 years - 5 ml( 0.156 g / 5 ml);Children aged 9 months. Up to 2 years - 2.5 ml of syrup( 0.156 g / 5 ml) 3 times a day. In severe infections, these doses can be doubled.
Adults and children over 12 years of age with light and moderate infections are prescribed 1 tablet( 0.375 g) 3 times a day. In severe infection, a single dose of 1 tab. On 0,625 g or 2 tab.0.375 g 3 times a day.
Intravenous administration of
In severe infection, the drug is administered intravenously in a single dose of 1.2 g every 6-8 hours. If necessary, the drug can be injected every 6 hours. The maximum single dose is 1.2 g, the maximum allowable daily dose for intravenous administration -7.2 g.
Patients with impaired renal excretory function of the middle or severe degree require correction of the dosing regimen of the drug. With the clearance of creatinine( the rate of purification of blood from the final product of nitrogen metabolism -: creatinine) more than 30 ml / min, there is no need to change the dosage regimen;At 10-30 ml / min - the initial dose of the drug is 1.2 g intravenously, then 0.6 g every 12 hours. With a creatinine clearance less than 10 ml / min, the initial dose of the drug is 1.2 g, then 0.6 gEvery 24 hours. Augmentin is excreted in dialysis( a method of blood purification).In the case of the drug in patients on dialysis, an additional intravenous dose of 0.6 g at the time and 0.6 g at the end of the dialysis procedure is prescribed.
Augmentin should not be mixed in a single syringe or dropper with aminoglycoside antibiotics, as the inactivation( loss of activity) of the latter occurs. The drug should not be mixed with blood products and protein-containing( protein-containing) fluids.
Side effects of Augmentin
On the part of the digestive system: nausea, vomiting, diarrhea, impaired liver function, increased activity of "liver" transaminases, in isolated cases - cholestatic jaundice, hepatitis, pseudomembranous colitis. Allergic reactions: urticaria, erythematous eruptions, rarely - multiforme exudative erythema, anaphylactic shock, angioedema, extremely rarely - exfoliative dermatitis, malignant exudative erythema( Stevens-Johnson syndrome).Local reactions: in some cases, phlebitis in the place of intravenous administration. Other: candidamycosis, development of superinfection, reversible increase in prothrombin time.
To whom is contraindicated Augmentin
To persons with hypersensitivity to the components of the drug.
Intravenously should be used with caution in patients with severe impairment of liver function. When hives or erythematous rash appear, treatment should be discontinued.
Use of the drug during pregnancy( especially in the first trimester) and breastfeeding is not recommended.
The drug should be administered with caution to patients with an indication of allergic reactions in the anamnesis( medical history).
Interactions of Augmentin
It is not recommended to use Augmentin concurrently with probenecid. Probenecid reduces tubular secretion of amoxicillin, and therefore simultaneous use of Augmentin and probenecid can lead to an increase and persistence in the blood levels of amoxicillin, but not clavulanic acid.
With the simultaneous use of allopurinol and amoxicillin, an increased risk of allergic reactions is possible. Data on concomitant application of Augmentin and allopurinol are currently not available.
Like other broad-spectrum antibiotics, Augmentin can reduce the effectiveness of oral contraceptives.
Overdose of Augmentin
In case of an overdose, gastrointestinal disturbances and water-electrolyte balance disorders are possible. Amoxicillin crystalluria is described, in some cases leading to the development of renal failure.