Perhaps it is difficult to find a diagnosis that would cause as conflicting emotions as depression. This disease can be called an exceptional phenomenon in psychiatry. Patients do not hesitate to "depressed".On the contrary, it is one of the most elitist diagnoses all over the world.
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Of the five most sold drugs in the world - three antidepressants. Despite the fact that the volume of the pharmaceutical market varies insignificantly, the market of antidepressants annually doubles.
The prevalence statistics for depression are also impressive. If the total mass of depression, post-traumatic and anxiety disorders affects about 10% of the population, then in major cities, this figure reaches 20%.
What is depression?
It would seem that the answer is obvious: an oppressed state, a bad mood, connected with some troubles. In fact, it is far from the "real" depression. Firstly, because the mood is not always overwhelming. Secondly, depression is always endogenous and not r
A person simply loses the ability to receive satisfaction from life. The syndrome of posttraumatic disorders, which is often confused with depression, is really connected exclusively with external factors( rape, arrests, etc.) And with anxiety disorders a person can not concentrate: he speaks incoherently, grabs in several cases and can not bring them to their logical conclusion.
Depression in the eyes of biochemistry
Development of depression depends on three mediators( norepinephrine, serotonin, dopamine), which ensure the transmission of nerve impulses in the synapses of the brain. When they are not enough, the neuron perceiving the information turns out to be "dissatisfied".In order to correct the situation, it is necessary to increase the number of the mediator.
The blockade of their amine destroying them is an indiscriminate reaction, therefore, monoamine oxidase inhibitors have many side effects. The class of serotonin reuptake inhibitors is the most promising.
It is quite scarce. In order for its expenditure to be economical, the transmitting neuron captures unbound serotonin back. The problem arises from the fact that there is too much of the receptor depression, and the binding rate with them is not high. Therefore, the neuron captures the serotonin even before it could contact the host neuron. If to prevent back capture, the neuron will remain "satisfied" and the symptoms will disappear. However, this is the "do" antidepressant drugs, which can be used for a very wide range of disorders: depression, post-traumatic disorders, anxiety.
Useful facts about depression
- This is the main cause of suicide. There is a general rule: if a person has ever talked about suicide, he needs to talk with a psychotherapist.
- With depression it is impossible to cope with effort of will. Also, it is impossible to reduce the blood sugar level in diabetes by auto-training. They are based on biochemical processes. Therefore, one should not dissuade patients from treatment or critically speak about prescribed medications. If progressive depression is treated with Corvalol, it can develop into a "big psychiatry"!
- Antidepressants are not drugs, not tranquilizers, not antipsychotics. They do not cause euphoria, sedation and addiction.
- Antidepressants are a new class of drugs that do not depress the psyche, but eliminate the underlying cause.